Selective Modulation of B-cell MarkerS of activation, inhiBition and exhauStion with vaSoactive inteStinal PePtide (viP) in aSyMPtoMatic

Effect of an Antagonist of Vasoactive Intestinal Polypeptide on Biological Rhythm of Rest Activity in the Rat

Abstract Vasoactive Intestinal Polypeptide (VIP), has been found in different neurotransmitter systems and exists in various nerve tracts in the brain. Potential role of this peptide in physiological processes such as regulation of sleep and wakefulness, and biological rhythms has been confirmed in several reports. In the present research effects of intracerebroventricular (ICV) injection of a...

Human Plasmacytoid Dendritic Cell Function: Inhibition of IFN- Secretion and Modulation of Immune Phenotype by Vasoactive Intestinal Peptide

Cholinergic agonists interact with immunomodulatory actions of neuropeptides VIP and SP

INTRODUCTION Vagus nerve activity ameliorates intestinal inflammation. Its mechanisms may involve attenuation of pro-inflammatory cytokine production by macrophages (MF) and inhibition of inflammatory processes via the release of acetylcholine (ACh). However, vagus nerve stimulation may also modulate the release of neuropeptides with immune-modulatory potential, such as substance P (SP) and vas...

Vasoactive intestinal peptide modulates Langerhans cell immune function.

Epidermal nerves lie in close proximity to Langerhans cells (LC) and are capable of releasing peptides that modulate LC function, including calcitonin gene-related peptide and pituitary adenylate cyclase-activating polypeptide. The neuropeptide vasoactive intestinal peptide (VIP) has also been found in cutaneous nerves and mRNA, for the VIP receptor vasoactive intestinal peptide receptor type 1...

Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia

Objective(s): The main objective of this study was to investigate the variations of β-endorphin (β-EP), vasoactive intestinal peptide (VIP), serotonin (5-HT) and norepinephrine (NE) of immune thrombocytopenia (ITP) mice as well as the regulatory mechanism of prednison. Materials and Methods: Sixty BALB/c mice were randomly divided into control group, model group and prednison intervention grou...